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Tocris Bioscience™ SPRi 3
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Product Code. 18788056
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Product Code. 18788056 Supplier Tocris Bioscience™ Supplier No. 6597/10

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166.60 GBP valid until 2026-03-31
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Description

Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR); attenuates proliferation of CD4+ T cells

SPRi 3 is a potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.
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Specifications

Chemical Name or Material N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
CAS 1292285-54-1
Quantity 10 mg
Molecular Formula C14H18N2O3
Formula Weight 262.3
Purity 98%
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