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Invitrogen™ RUNX2 Monoclonal Antibody (ZR002)
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Product Code. 10119502
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100 μg
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10119502 100 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10119502 Supplier Invitrogen™ Supplier No. 411400

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

RUNX2 Monoclonal Antibody for Western Blot, ELISA

RUNX2, a nuclear protein, is a member of the RUNX family of transcription factors and has an Runt DNA-binding domain. It is essential for membranous and endochondral bone formation. It not only regulates osteoblastic differentiation and skeletal morphogenesis but also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer and with more affinity, as a subunit of a heterodimeric complex. It plays a critical role in increasing TGFBR1 expression by osteoblasts and functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. Mutations lead to disorders in bone development like cleidocranial dysplasia (CCD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen RUNX2
Applications ELISA, Western Blot
Classification Monoclonal
Clone ZR002
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene RUNX2
Gene Accession No. Q13950
Gene Alias Acute myeloid leukemia 3 protein; AKV core binding factor; Aml3; AML-3; Cbf; Cbfa1; Cbfa-1; CBF-alpha-1; CCD; CCD1; CLCD; core binding factor alpha 1; core binding factor alpha 1 subunit; core-binding factor subunit alpha-1; core-binding factor, runt domain, alpha subunit 1; LOW QUALITY PROTEIN: runt-related transcription factor 2; LS3; Oncogene AML-3; Osf2; OSF-2; osteoblast-specific transcription factor 2; PEA2aA; PEA2-alpha A; PEBP2 alpha A; PEBP2A; Pebp2a1; PEBP2aA; PEBP2-alpha A; Pebpa2a; Polyomavirus enhancer-binding protein 2 alpha A subunit; runt domain, alpha subunit 1; runt related transcription factor 2; runt-related transcription factor 2; RUNX 2; RUNX family transcription factor 2; Runx2; RUNX-2; SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; transcription factor RUNX2; transcription factor RUNX2/CBFA1
Gene Symbols RUNX2
Host Species Mouse
Immunogen Synthetic peptide derived from the C-terminal region of the human and mouse Runx2 proteins.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 860
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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