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Invitrogen™ PTBP1 Monoclonal Antibody (1)
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Product Code. 10027612
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100 μg
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10027612 100 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10027612 Supplier Invitrogen™ Supplier No. 324800

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

This antibody reacts with the C-terminus of the human and rodent PTB protein.

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTBP1
Applications Flow Cytometry, Immunoprecipitation, Western Blot, RNA Immunoprecipitation, Immunocytochemistry
Classification Monoclonal
Clone 1
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene PTBP1
Gene Accession No. P17225, P26599, Q00438
Gene Alias 57 kDa RNA-binding protein PPTB-1; AA407203; AL033359; Heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; HNRNPI; HNRNP-I; HNRPI; MGC10830; MGC8461; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract binding protein 1; polypyrimidine tract-binding protein; polypyrimidine tract-binding protein 1; polypyrimidine-tract binding protein; pPTB; PTB; PTB-1; PTB2; PTB3; PTB4; PTBP1; PTB-T; Pybp; Pybp1; Pybp2; pyrimidine binding protein 1; pyrimidine binding protein 2; RNA-binding protein
Gene Symbols PTBP1
Host Species Mouse
Immunogen Recombinant human PTB protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19205, 29497, 5725
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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