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Invitrogen™ PPY Polyclonal Antibody
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Quantity:
100 μL
Unit Size:
100µL
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17218503 100 μL 100µL
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Product Code. 17218503 Supplier Invitrogen™ Supplier No. PA5115719

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Pancreatic Polypeptide.

The PPY gene encodes pancreatic polypeptide, a peptide hormone involved in the regulation of appetite and energy balance. The origin of the PPY gene is linked to a tandem duplication of the PYY gene, occurring concomitantly with the emergence of tetrapods, leading to the distinct PPY function within the neuropeptide Y family. In primates and ungulates, a gene duplication event resulted in the formation of a PYY2-PPY2 gene cluster, highlighting the evolutionary complexity of these genes. The PPY gene product is secreted by gamma-cells in the pancreas, localized primarily in the islet periphery, and plays a crucial role in metabolic homeostasis by interacting with receptors in the central nervous system to modulate satiety signals postprandially. PPY's function is linked to its inhibition of AGRP/NPY neurons which decreases their suppressive effect on POMC neurons, enhancing POMC activity and contributing to appetite suppression. This intricate regulation underscores the importance of PPY in dietary intake and metabolic disorders, with ongoing research exploring its potential therapeutic applications.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PPY
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene PPY
Gene Accession No. P01298, P06303, P10601
Gene Alias AV061413; C-terminal peptide; HGNC:9327; IGSPP; IOPPP; Obinepitide; panceatic polypeptide; Pancreatic hormone; Pancreatic icosapeptide; Pancreatic polypeptide; pancreatic polypeptide Y; pancreatic prohormone; Pancreatic prohormone percursor; pancreatic prohormone precursor; PH; PI; PNP; PP; PP1; PPA1; PPase; Ppy; prepro-PP (prepropancreatic polypeptide); SID6-8061
Gene Symbols PPY
Host Species Rabbit
Immunogen A synthesized peptide derived from human PPY(Accession P01298), corresponding to amino acid residues A41-S91.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19064, 24677, 5539
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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