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Invitrogen™ Phospho-PKC gamma (Thr655) Polyclonal Antibody
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Product Code. 10057622
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10057622 Supplier Invitrogen™ Supplier No. 44965

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Rabbit Polyclonal Antibody

Phospho-PKC gamma (Thr655) Polyclonal Antibody for Western Blot, IHC (P)

The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PKC gamma (Thr655)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
Gene PRKCG
Gene Accession No. P05129, P63318
Gene Alias PKC; Pkcc; PKCG; PKCgamma; PKC-gamma; PKCI; Prkc; Prkcc; PRKCG; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma; RATPKCI; SCA14
Gene Symbols PRKCG
Host Species Rabbit
Immunogen The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human PKC-gamma that contains threonine 655.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18752, 5582
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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