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Phospho-CD61 (Tyr785) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen 44878

Code : 50

Additional Details : Weight : 0.05000kg

Product Code. 10008482

  • £395.00 / Each
Estimated Shipment: 13-06-2024
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For Research Use Only. All usage must comply with product instructions.
 

Description

Description

CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
Specifications

Specifications

Phospho-CD61 (Tyr785)
Polyclonal
Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
P05106
ITGB3
The antiserum was produced against a chemically synthesized phosphopeptide derived from the c-terminus of the Integrin beta-3 receptor
100 μL
Primary
Human
Antibody
IgG
Immunoprecipitation, Western Blot
Unconjugated
ITGB3
antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGK_08849; glycoprotein GPIIIa; glycoprotein IIIa; GP3A; GPIIIa; GT; INGRB3; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin beta-3 subunit; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; platelet membrane glycoprotein IIIa
Rabbit
Antigen affinity chromatography
RUO
3690
-20°C
Liquid
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