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Invitrogen™ PDHA1 Monoclonal Antibody (8D10E6)

Product Code. 10194853
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100 μg
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10194853 100 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10194853 Supplier Invitrogen™ Supplier No. 456600

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

When performing ICC and IF heat-induced antigen-retrieval improves signal. When performing Flow Cytometry Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Positive Control: WB: Isolated mitochondria from human, bovine, rat and mouse heart. HepG2 (human liver hepatocellular carcinoma cell line) cell lysate. FACS: HeLa (human epithelial cell line from cervix adenocarcinoma) and HL-60 (human promyelocytic leukemia cell line) cells.

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDHA1
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 8D10E6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation HEPES buffered saline with 0.02% sodium azide
Gene PDHA1
Gene Accession No. A7MB35, P08559, P26284, P35486
Gene Alias PDHA; PDHA1; Pdha-1; PDHAD; PDHCE1A; PDHE1-A type I; PHE1A; pyruvate dehydrogenase; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase complex, E1-alpha polypeptide 1; pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component alpha subunit; pyruvate dehydrogenase E1 component alpha subunit precursor; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1 subunit; pyruvate dehydrogenase E1 subunit alpha 1; pyruvate dehydrogenase E1alpha subunit
Gene Symbols PDHA1
Host Species Mouse
Immunogen Human recombinant PDH-E1-alpha.
Purification Method IgG fraction
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18597, 29554, 407109, 5160
Target Species Human, Mouse, Rat, Bovine, Drosophila
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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