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DiscoverX PathHunter™ CCR5 Activated GPCR Internalization U2OS Cell Line

Product Code. 17343599
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17343599 2 Vials 2 ampoules
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Product Code. 17343599 Supplier DiscoverX Supplier No. 930653C3

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Description

The PathHunter™ CCR5 Activated GPCR Internalization U2OS Cell Line measures CCR5 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ CCR5 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. CCL3/MIP-1α) based internalization of CCR5 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged CCR5. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting CCR5-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Receptor Internalization
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist Recombinant Human MIP-1α (CCL3)
Quantity 2 Vials
Target Entry CCR5
Accession Number BC038398
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