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Invitrogen™ Pannexin 3 Polyclonal Antibody
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Product Code. 10175123
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Quantity:
100 μg
Unit Size:
100µg
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10175123 100 μg 100µg
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10175123 Supplier Invitrogen™ Supplier No. 433270

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Rabbit Polyclonal Antibody

Pannexin 3 Polyclonal Antibody for Western Blot, ICC/IF

Pannexins constitute a new family of gap junction type proteins. They are highly conserved in worms, mollusks, insects and mammals and are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop and intracellular N- and C-termini. Besides the connexin proteins, Pannexin 1 and 2 seem to be molecular components of neuronal gap junctions ('electrical synapses') that are thought to form connections between principal cells in the hippocampus. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions. In addition to forming gap junction channels in paired oocytes, Pannexin 1 can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Pannexin 1 and 3 are both glycoproteins with a cell surface distribution profile and life cycle dynamics distinct from connexin 43. Pannexin 3 expression was prevalent in skin and cartilage. In transiently expressing cells both pannexin 1 and 3 were incapable of forming intercellular channels but assembled into functional cell surface channels. Suggested roles in the ischemic death of neurons, schizophrenia, inflammation and tumor suppression have drawn attention for properties and cellular functions of pannexins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Pannexin 3
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene PANX3
Gene Accession No. P60572, Q8CEG0, Q96QZ0
Gene Alias 3230401P04; 4833413G11Rik; gap junction protein pannexin 3; pannexin 3; pannexin-3; Panx3; Px3; si:dkey-263o8.2
Gene Symbols PANX3
Host Species Rabbit
Immunogen Synthetic peptide derived from the C-terminal region of the mouse and rat Pannexin 3 protein.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116337, 208098, 315567
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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