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Invitrogen™ P-cadherin Monoclonal Antibody (12H6)
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Product Code. 10189632
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100 μg
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10189632 100 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10189632 Supplier Invitrogen™ Supplier No. 324000

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

32-4000 has successfully been used in western blot to detect P-cadherin in MDCK cell lysates.

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen P-cadherin
Applications Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone 12H6
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene Cdh3
Gene Accession No. P22223
Gene Alias AI385538; CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3; cadherin 3, type 1, P-cadherin (placental); cadherin-3; Cadp; calcium-dependent adhesion protein, placental; CDH3; CDHP; HJMD; PCAD; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin
Gene Symbols Cdh3
Host Species Mouse
Immunogen Human P-Cadherin fusion protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1001, 611010
Target Species Human, Canine
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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