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Invitrogen™ Occludin Monoclonal Antibody (OC-3F10), Alexa Fluor™ 488

Product Code. 10073504
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100 μg
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10073504 100 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10073504 Supplier Invitrogen™ Supplier No. 331588

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

Reactivity of this antibody with the occludin protein has been confirmed by immunofluorescence and western blotting (unconjugated). This antibody reacts specifically with mammalian occludin. Tissues/lysates that were tested with this antibody include T84 cell line (human intestinal epithelium), MDCK cells (canine kidney), Caco-2 cells (human colon adenocarcinoma), MTE7B (Mouse), and rat liver.

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Occludin
Applications ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone OC-3F10
Concentration 0.5 mg/mL
Conjugate Alexa Fluor 488
Formulation PBS with 4.0mg/mL BSA and 0.1% sodium azide; pH 7.4
Gene OCLN
Gene Accession No. Q16625, Q28269, Q61146, Q6P6T5
Gene Alias AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein
Gene Symbols OCLN
Host Species Mouse
Immunogen GST-fusion protein consisting of the C-terminal region (~150 aa) of human occludin.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100506658, 18260, 403844, 83497
Target Species Human, Mouse, Rat, Canine
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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