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Invitrogen™ MARCO Monoclonal Antibody (PLK-1)

Product Code. 10121894
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Quantity:
100 μg
Unit Size:
100µg
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10121894 100 μg 100µg
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Product Code. 10121894 Supplier Invitrogen™ Supplier No. MA140315

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Description

Mouse Monoclonal Antibody

Endotoxin: 0.40 EU/mg Application Notes: IHC (frozen) - tissue sections can be fixed in acetone or 2% paraformaldehyde. Western blot - use non-reducing conditions. Flow - this antibody weakly stains alveolar macrophages by recognizing the extracellular domain of MARCO, with transfected COS cells used as a positive control. Immunoprecipitation - will immunoprecipitate MARCO as a 60 kDa and 50 kDa protein from transfected COS lysates. Functional Assays - blocks human alveolar macrophages by recognizing the extracellular doamin of MARCO. Recommended positive control: Human alveolar macrophages; Negative control: All other human cells.

MARCO, also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family. As a part of the innate antimicrobial immune system, MARCO can bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. Due to its expression in tumor infiltrating macrophages, and its role in inhibiting immune responses within tumor environment, MARCO has been indicated as a potential target for cancer immunotherapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MARCO
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone PLK-1
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene Marco
Gene Accession No. Q9UEW3
Gene Alias AI323439; Ly112; macrophage receptor MARCO; Macrophage receptor with collagenous structure; MARCO; SCARA2; Scavenger receptor class A member 2; scavenger receptor class A, member 2; SR-A6
Gene Symbols Marco
Host Species Mouse
Immunogen Human alveolar macrophages (recognizes domain V between residues 420 and 431).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 505632, 8685
Target Species Human, Bovine
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG3
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