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  4. Invitrogen™ Human MAP2K1 (MEK1) [S218D, S222D], His Tag Recombinant Protein

Invitrogen™ Human MAP2K1 (MEK1) [S218D, S222D], His Tag Recombinant Protein

Product Code. 10185102
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1 mg
Unit Size:
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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10185102 Supplier Invitrogen™ Supplier No. PV4004

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

MAP2K1 (MEK1) kinase is a dual-specific protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. This mutant has been activated by substituting serines 218 and 222 with aspartic acid to mimic the phosphorylated state. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris with 150mM NaCl, 0.05% NP-40, 0.05mM EDTA, 50% glycerol, 1mM DTT and no preservative; pH 7.5
Molecular Weight (g/mol) 49.2 kDa
Name Human MAP2K1 (MEK1) [S218D, S222D], His Tag
pH Range 7.5
Purification Method Purified
Quantity 1 mg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Common Name MEK1 (S218D, S222D Mutant)
KinaseFamily STE7 Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Kinase Group Ser/Thr Kinases: STE Group
Shipping Condition Dry Ice
Expression System Baculovirus
Protein Form Full Length
Form Liquid
Research Category Drug Development
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