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  5. Tocris Bioscience™ JNJ 0966

Tocris Bioscience™ JNJ 0966
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Product Code. 18706796
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18706796 10 mg 10mg
18786616 50 mg 50mg
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Product Code. 18706796 Supplier Tocris Bioscience™ Supplier No. 6439/10

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Description

Pro-MMP9 activation inhibitor (IC50 = 440 nM)

JNJ 0966 is a pro-MMP9 activation inhibitor (IC50 = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.
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Specifications

Chemical Name or Material N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide
CAS 315705-75-0
Quantity 10 mg
Molecular Formula C16H16N4O2S2
Formula Weight 360.45
Purity 98%
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