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Invitrogen™ JAK2 Monoclonal Antibody (691R5)
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Product Code. 10129302
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100 μg
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10129302 100 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10129302 Supplier Invitrogen™ Supplier No. AHO1352

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

JAK2 Monoclonal Antibody for Western Blot

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JAK2
Applications Western Blot
Classification Monoclonal
Clone 691R5
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide; pH 7.2
Gene JAK2
Gene Accession No. O60674, Q62120, Q62689
Gene Alias EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
Gene Symbols JAK2
Host Species Mouse
Immunogen Recombinant fragment of human JAK2 expressed in E. coli.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16452, 24514, 3717
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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