Invitrogen™ HRD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA512093

Product Code. 10028649

Description

HRD1 Polyclonal Antibody for Western Blot, IHC (P), ICC/IF

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.

Specifications

• Antigen: HRD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SYVN1
• Gene Alias: 1200010C09Rik; AW211966; C85322; D530017H19Rik; DER3; E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog; Hrd1; HRD1 protein; KIAA1810; MGC40372; RGD1310488; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1; synovial apoptosis inhibitor 1, synoviolin; synoviolin 1; Syvn1
• Host Species: Rabbit
• Purification Method: Size-exclusion - Dialysis, Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 74126, 84447
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.8 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q86TM6, Q9DBY1
• Gene Symbols: SYVN1
• Immunogen: KLH conjugated synthetic peptide between 586-617 amino acids from the C-terminal region of human SYVN1 (HRD1).
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG