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  5. Tocris Bioscience™ GW 583340 dihydrochloride

Tocris Bioscience™ GW 583340 dihydrochloride
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Product Code. 18782544
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
Product Code. Quantity unitSize
18782544 10 mg 10mg
18752524 50 mg 50mg
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Product Code. 18782544

Brand: Tocris Bioscience™ 2239/10

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Description

Potent dual EGFR/ErbB2 inhibitor; orally active

Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ∽ 80% in a murine xenograft model following oral administration.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1173023-85-2
Molecular Formula C28H27Cl3FN5O3S2

Specifications

Quantity 10 mg
Formula Weight 671.03
Purity >97%
Molecular Weight (g/mol) 671.024
Chemical Name or Material GW 583340 dihydrochloride
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