Invitrogen™ Fetal Hemoglobin Monoclonal Antibody (HBF-1), PE

Product Code.	Quantity	unitSize
10120383	500 μL	Each

Product Code. 10120383 Supplier Invitrogen™ Supplier No. MHFH04

Description

Mouse Monoclonal Antibody

R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients. This antibody specifically recognizes fetal hemoglobin found in fetal erythrocytes.

Hemorrhage of cells from an Rh+ fetus into the circulation of an Rh- mother may result in the formation of Rh-reactive antibodies in the mother. Rh hemolytic anemia in a subsequent Rh+ fetus may result from placental transfer of antibodies formed in the mother to the fetus. Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects. Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells. These cells have been termed F cells. High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin. Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells. Several clinical conditions have been described with increased levels of F cells. These conditions include hereditary anemic diseases such as sickle cell anemia and thalassemia major.

Specifications

• Antigen: Fetal Hemoglobin, Fetal Hemoglobin (HbF)
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: HBF-1
• Conjugate: PE
• Formulation: PBS with BSA, <10% sucrose and 0.1% sodium azide
• Gene: HBG1
• Gene Accession No.: P69891
• Gene Alias: A-gamma globin; alpha-1 globin; gamma A hemoglobin; gamma globin; gamma-1-globin; Hb F Agamma; HBG1; HBGA; HBGR; HBG-T2; hemoglobin alpha 1; Hemoglobin gamma-1 chain; hemoglobin gamma-a chain; hemoglobin subunit gamma 1; hemoglobin subunit gamma-1; hemoglobin, gamma A; hemoglobin, gamma, regulator of; HSGGL1; PRO2979
• Gene Symbols: HBG1
• Host Species: Mouse
• Immunogen: Human Fetal Hemoglobin (HbF).
• Purification Method: purified
• Quantity: 500 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3047
• Target Species: Human
• Content And Storage: 4°C, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1