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  6. Invitrogen™ Factor XIII Recombinant Rabbit Monoclonal Antibody (K01_1K61)

Invitrogen™ Factor XIII Recombinant Rabbit Monoclonal Antibody (K01_1K61)
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Product Code. 30825410
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30827418 50 μL
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Product Code. 30825410 Supplier Invitrogen™ Supplier No. MA563314

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Description

Rabbit Recombinant Monoclonal Antibody

Factor XIII Recombinant Monoclonal Antibody for IHC (P), Western Blot

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
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Specifications

Antigen Factor XIII
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone K01_1K61
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 150mM NaCl, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene F13A1
Gene Accession No. P00488
Gene Alias bA525O21.1 (coagulation factor XIII, A1 polypeptide); coagulation factor XIII; coagulation factor XIII A chain; Coagulation factor XIII B chain; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; coagulation factor XIII, B polypeptide; coagulation factor XIIIa; F13; F13A; F13A1; F13B; Factor 13; factor viiia; factor XIIIa; Factor13; fibrin stabilizing factor, A subunit; fibrinoligase; fibrin-stabilizing factor B subunit; FSF, A subunit; FXIIIB; Protein-glutamine gamma-glutamyltransferase A chain; protein-glutamine gamma-glutamyltransferase B chain; TGase; transglutaminase A chain; Transglutaminase B chain; transglutaminase. plasma
Gene Symbols F13A1
Host Species Rabbit
Immunogen Recombinant protein of human Factor XIIIa.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2162
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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