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Invitrogen™ Cyclophilin B Polyclonal Antibody
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Product Code. 10141030
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Quantity:
100 μg
Unit Size:
100µg
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10141030 100 μg 100µg
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Product Code. 10141030 Supplier Invitrogen™ Supplier No. TAB1002

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Description

Rabbit Polyclonal Antibody

TAB1002 detects Cyclophilin B in samples TAB1002 has been successfully been used in Western Blot applications The TAB1002 immunogen is a KLH conjugated peptide corresponding to human cyclophilin B.

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclophilin B
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation BBS with no preservative; pH 8.4
Gene PPIB
Gene Accession No. P23284, P24369
Gene Alias AA408962; AA553318; AI844835; Cphn2; Cphn-2; cyclophilin B; cyclophilin-like protein; Cyp B; CyP-20b; CYPB; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; HEL-S-39; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Ppib; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP
Gene Symbols PPIB
Host Species Rabbit
Immunogen KLH conjugated peptide representing human cyclophilin B.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19035, 5479
Target Species Human, Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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