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Invitrogen™ Connexin 46 Polyclonal Antibody
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Product Code. 10078549
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Quantity:
400 μL
Unit Size:
100µg
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10078549 400 μL 100µg
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Product Code. 10078549 Supplier Invitrogen™ Supplier No. PA511634

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Description

Rabbit Polyclonal Antibody

Connexin 46 Polyclonal Antibody for Western Blot, IHC (P)

Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46 and C2P3, maps to human chromosome 13q11-q12 and encodes a 46 kDa protein. Cx46, along with Cx50, is principally expressed in the lens of the eye. Cx46 mediates intercellular interactions during development and is necessary for the survival of neural crest cells. Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency and normal lens function. Mutations of Cx46 result in severe cataracts of the lens. Individual knockouts of Cx46 and Cx50 lead to changes in the rate of lens fiber cell differentiation and cell size, thus the interaction of Cx46 and Cx50 is required for proper organization of fiber cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Connexin 46
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene GJA3
Gene Accession No. Q9Y6H8
Gene Alias alpha 3 connexin; Cnx46; connexin 46; connexin-46; CTRCT14; Cx43; CX46; Cxn-46; CZP3; gap junction alpha 3; gap junction alpha-3 protein; gap junction membrane channel protein alpha 3; gap junction protein alpha 3; gap junction protein, alpha 3; gap junction protein, alpha 3, 46kDa; Gja3; Gja-3
Gene Symbols GJA3
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 108-139 amino acids from the N-terminal region of human GJA3.
Purification Method Ammonium sulfate precipitation, Size-exclusion - Dialysis
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2700
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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