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Invitrogen™ Connexin 26 Monoclonal Antibody (CX-12H10)

Product Code. 10118972
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100 μg
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10118972 100 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10118972 Supplier Invitrogen™ Supplier No. 138100

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

13-8100 reacts strongly with Connexin-26, which has a predicted molecular weight of 26.5 kDa. Reactivity of this antibody on western blots has been confirmed by using extracts from mouse liver, mouse brain, and rat brain and it appears to exhibit minimal cross-reaction with Cx30 by western blotting. The degree of cross-reaction with Cx30 by IHC is uncertain, but may be influenced by fixation conditions.

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Connexin 26
Applications ELISA, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone CX-12H10
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene Gjb2
Gene Accession No. P21994, P29033, Q00977
Gene Alias AI325222; Cnx26; connexin 26; connexin-26; CX26; CXN-26; DFNA3; DFNA3A; DFNB1; DFNB1A; Gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; gap junction protein beta 2; gap junction protein, beta 2; gap junction protein, beta 2, 26kDa; GJB2; Gjb-2; HID; KID; mutant gap junction protein beta 2; NSRD1; PPK
Gene Symbols Gjb2
Host Species Mouse
Immunogen Synthetic peptide corresponding to a segment of the cytoplasmic loop of rat Connexin-26.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14619, 2706, 394266
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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