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Invitrogen™ Claudin 4 Monoclonal Antibody (3E2C1), Alexa Fluor™ 488
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Product Code. 10053744
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100 μg
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10053744 100 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10053744 Supplier Invitrogen™ Supplier No. 329488

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

Claudin 4 Monoclonal Antibody for IHC (P)

Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl- permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
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Specifications

Antigen Claudin 4
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 3E2C1
Concentration 0.5 mg/mL
Conjugate Alexa Fluor 488
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene Cldn4
Gene Accession No. O14493, O35054
Gene Alias Cep-r; claudin 4; CLAUDIN4; claudin-4; CLDN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPER; CPE-R; CPE-receptor; Cpetr; CPETR1; h CPE-receptor; hCPE-R; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein
Gene Symbols Cldn4
Host Species Mouse
Immunogen Synthetic peptide corresponding to a 22 amino acid sequence derived from the C-terminal region of human Claudin-4.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100856416, 12740, 1364, 304407
Target Species Human, Mouse, Rat, Canine
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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