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Invitrogen™ CDK12 Polyclonal Antibody
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Product Code. 10140990
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Quantity:
400 μL
Unit Size:
100µg
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Product Code. Quantity unitSize
10140990 400 μL 100µg
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Product Code. 10140990 Supplier Invitrogen™ Supplier No. PA514462

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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with rat based on sequence homology.

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK12
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene CDK12
Gene Accession No. Q14AX6, Q9NYV4
Gene Alias 1810022J16Rik; AI646528; CDC2-related kinase 7; CDC2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; Cdk12; Cell division cycle 2-related protein kinase 7; cell division protein kinase 12; CRK7; CRKR; Crkrs; cyclin dependent kinase 12; cyclin-dependent kinase 12; cyclin-dependent kinase 12 isoform; D11Ertd752e; H KIAA0904; hCDK12; Kiaa0904; Pksc; Protein kinase for splicing component
Gene Symbols CDK12
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CrkRS (CRK7).
Purification Method Ammonium sulfate precipitation, Size-exclusion - Dialysis
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51755, 69131
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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