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Invitrogen™ CD81 Monoclonal Antibody (2F7), FITC
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Product Code. 10093864
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500 μg
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10093864 500 μg Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10093864 Supplier Invitrogen™ Supplier No. HMCD8101

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Armenian Hamster Monoclonal Antibody

CD81 Monoclonal Antibody for Flow

CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD81
Applications Flow Cytometry
Classification Monoclonal
Clone 2F7
Concentration 0.5 mg/mL
Conjugate FITC
Formulation PBS with <0.1% sodium azide; pH 7.4
Gene CD81
Gene Accession No. P35762
Gene Alias 26 kDa cell surface protein TAPA-1; CD 81 antigen; Cd81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CD81 molecule; CVID6; S5.7; Tapa1; Tapa-1; Target of the antiproliferative antibody 1; Tetraspanin28; tetraspanin-28; Tspan28; Tspan-28
Gene Symbols CD81
Host Species Armenian Hamster
Immunogen Mouse CD81 (TAPA-1). from Mouse epithelial cell line PAM212.
Purification Method Purified
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100759632, 12520
Target Species Hamster, Mouse
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG3
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