Invitrogen™ CD7 Monoclonal Antibody (CD7-6B7), FITC

Product Code.	Quantity	unitSize
10169852	500 μL	Each

Product Code. 10169852 Supplier Invitrogen™ Supplier No. MHCD0701

Description

Mouse Monoclonal Antibody

Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.

CD7, also known as gp40 or Leu9, is a 40 kDa receptor and member of the immunoglobulin gene superfamily. It features an N-terminal region (amino acids 1-107) that is highly homologous to Ig kappa light chains, while its carboxyl-terminal region is proline-rich, forming a stalk from which the Ig domain projects. CD7 is prominently expressed on the majority of immature and mature T lymphocytes, as well as T cell leukemias. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. CD7 plays a crucial role in modulating immune cell activity. Cross-linking of surface CD7 enhances T cell and NK cell functions, as evidenced by increased calcium flux, expression of adhesion molecules, cytokine secretion, and proliferation. CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces the production of D-3 phosphoinositides and tyrosine phosphorylation. The expression of CD7 is an important marker in leukemia diagnostics, highlighting its significance in both normal immune function and disease states.

Specifications

• Antigen: CD7
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: CD7-6B7
• Conjugate: FITC
• Formulation: PBS with 4mg/mL BSA and 0.1% sodium azide
• Gene: CD7
• Gene Accession No.: P09564
• Gene Alias: Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
• Gene Symbols: CD7
• Host Species: Mouse
• Immunogen: Human CD7.
• Purification Method: Purified
• Quantity: 500 μL
• Regulatory Status: ASR
• Primary or Secondary: Primary
• Gene ID (Entrez): 924
• Target Species: Human
• Content And Storage: 4°C, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a