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  6. Invitrogen™ CD28 Monoclonal Antibody (10F3)

Invitrogen™ CD28 Monoclonal Antibody (10F3)
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Product Code. 10078382
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500 μL
2 mL
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10078382 500 μL Each
10692964 2 mL Each
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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10078382 Supplier Invitrogen™ Supplier No. CD2800

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

CD28 Monoclonal Antibody for ICC/IF, Flow

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD28
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone 10F3
Conjugate Unconjugated
Formulation PBS with BSA and 0.1% sodium azide
Gene Cd28
Gene Accession No. P10747
Gene Alias antigen CD28; CD28; CD28 antigen; CD28 antigen (Tp44); CD28 isoform; CD28 isoform 2; Cd28 molecule; CD28 precursor protein; CD28 protein; CD28 protein precursor; CD28RNA; cell surface protein; CHT28; contains partial extracellular domain; costimulatory molecule B7 receptor CD28; EGK_04709; MGC138290; sCD28; soluble CD28; T44; T-cell costimulatory molecule CD28; T-cell costimulatory molecule Tp44; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28 homolog; TP44
Gene Symbols Cd28
Host Species Mouse
Immunogen Human CD28.
Purification Method Purified
Quantity 500 μL
Regulatory Status ASR
Primary or Secondary Primary
Gene ID (Entrez) 940
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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