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Bcl-X Monoclonal Antibody (2H12), Invitrogen™

Product Code. 10098242
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10098242 Supplier Invitrogen Supplier No. AHO0222

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

This antibody reacts with both Bcl-XS (short) and Bcl-XL (long) proteins. The immunogenic sequence (aa 3-14) is conserved in human and mice. Staining of formalin-fixed paraffin-embedded tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 20 min followed by cooling at room temperature for 20 min. A recommended positive control is Hodgkin's lymphoma.

Bcl-X has two isoforms, Bcl-XL (long), a 241 amino acid protein, and Bcl-XS (short), a 178 amino acid protein lacking a 63 amino acid domain that is well-conserved among members of the Bcl-2 family. This family of proteins is an important regulator of apoptosis. Bcl xL forms heterodimers with BAX, BAK, and Bcl2, and its overexpression in tumor cells confers resistance against chemotherapeutic drugs. Bcl xL is phosphorylated on many sites including serine 62, a critical site for Bcl xL response to microtubule-damaging drugs such as taxol and vinblastine. Phosphorylation of serine 62 is thought to be mediated by Jun N-terminal stress kinase (JNK) signaling - negatively regulates the anti-apoptotic function of Bcl xL and controls the growth of neoplastic cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bcl-X
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2H12
Concentration 0.2 mg/mL
Conjugate Unconjugated
Gene BCL2L1
Gene Accession No. Q07817, Q64373, O77737, P53563
Gene Alias Apoptosis regulator Bcl-X, BCL2L, BCL2L1, BCLX, BLC2L, Bcl-2-like 1 protein
Gene Symbols BCL2L1
Host Species Mouse
Immunogen A synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS), of human Bcl-X protein. Thisamino acid sequence is shared by human and murine Bcl-X protein.
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12048, 24888, 397536, 598
Target Species Human, Mouse, Pig, Rat
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a
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