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Eurofins DiscoverX ATR/ATRIP Protein, Active

Product Code. 17360844
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10 μg
250 μg
Unit Size:
10µg
250µg
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17360844 10 μg 10µg
17370844 250 μg 250µg
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Product Code. 17360844 Supplier Eurofins DiscoverX Supplier No. 14953

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Descripción

Active, Recombinant, human FLAG-tagged ATR full length (GenBank NM_001184.3*) and recombinant, human cMyc-tagged ATRIP full length, for use in Kinase Assays

Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.

GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference toGenBank NM_001184.3. M211T is reported inGenBank XM_001131387.1.

Especificaciones

Formulation mg/mL of enzyme in storage buffer.
Molecular Weight (g/mol) 303 kDa (ATR) and 87 kDa (ATRIP)
Quantity 10 μg
Species Human
Recombinant Recombinant
Protein Tag ATR-FLAG-tag / ATRIP-cMyc-tag
Expression System Recombinant enzyme expressed in mammalian cells
Protein Form Full-length
Purity or Quality Grade Combined ≥43% ration 1:1 to 2:1 ATR:ATRIP
Protein ATR/ATRIP, active
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