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CD31 Rat anti-Mouse, Unlabeled, Clone: MEC 13.3, BD

Product Code. 10082533
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Product Code. 10082533 Supplier BD Biosciences Supplier No. 550274

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Description

Rat Monoclonal Antibody

The MEC13.3 antibody reacts with CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1). CD31 is a 130 kDa integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. CD31 is expressed constitutively on the surface of adult and embryonic endothelial cells and is also expressed on many peripheral leukocytes and platelets. It has also been detected on bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 is involved in the transendothelial emigration of neutrophils, and neutrophil PECAM-1 appears to be down-regulated after extravasation into inflamed tissues. Multiple alternatively spliced isoforms are detected during early post-implantation embryonic development; this alternative splicing is involved in the regulation of ligand specificity. CD38 and vitronectin receptor ( α v β 3 integrin, CD51/CD61) are proposed to be ligands for CD31. CD31-mediated endothelial cell-cell interactions are involved in angiogenesis. The MEC13.3 mAb inhibits a variety of in vitro and in vivo functions mediated by CD31.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD31
Applications Flow Cytometry
Classification Monoclonal
Clone MEC 13.3
Concentration 15.625μg/mL
Conjugate Unconjugated
Description PECAM-1
Formulation Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
Host Species Rat
Immunogen 129/Sv mouse-derived endothelioma cell line tEnd.1
Purification Method Affinity Purified
Quantity 1 mL
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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For Research Use Only.

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