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ZO-1 Rat, Clone: R26.4C, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9776-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15557676

  • £146.13 / 100µg


EU Stock 2
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody R26.4C recognizes the tight junction protein 1, ZO-1 (zona occludens) of rat, mouse, canine, and porcine. ZO-1 is a member of the MAGUK family of tight junction associated scaffolding proteins, each containing a PDZ, SH3 and guanylate kinase-like (GUK) domain. ZO-1 is an integral member of the tight junction complex which forms a barrier to paracellular movement of substances, separating apical and basolateral fluids in relation to the epithelial cell layer. ZO-1 forms complexes with family members ZO-2, ZO-3, as well as occludin, cingulin, claudin-1-8, actin, alpha-catenin, the Ras-effector molecule AF-6, ZONAB, Apg-2, and the junctional adhesion molecules (JAM)-A-C. ZO-1 is thought to anchor the actin cytoskeleton to the tight junction. ZO-1 and ZO-2 have been shown to regulate cell cycle and proliferation with recent evidence highlighting the down-regulation of ZO-1 and ZO-2 with cancer progression.
Specifications

Specifications

ZO-1
R26.4C
Unconjugated
Purified
Rat
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Tight Junction Protein 1
IgG2a
RUO
Primary
Rat
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