ZO-1 Rat, Clone: R26.4C, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9776-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15557676

Quantity Price
1 £ 146.13 / 100µg
EU Stock 1
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Description and Specification

Specification

Quantity 100μg
Concentration 0.5mg/mL
Storage Requirements Store at 2-8°C.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Immunocytochemistry
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Applications Western Blotting
Format Purified
Primary or Secondary Primary
Regulatory Status RUO
Gene Alias Tight Junction Protein 1
Isotype IgG2a
Antigen ZO-1
Host Species Rat
Conjugate Unlabeled
Species Reactivity Canine, Mouse, Rat
Monoclonal or Polyclonal Monoclonal
Clone R26.4C

The monoclonal antibody R26.4C recognizes the tight junction protein 1, ZO-1 (zona occludens) of rat, mouse, canine, and porcine. ZO-1 is a member of the MAGUK family of tight junction associated scaffolding proteins, each containing a PDZ, SH3 and guanylate kinase-like (GUK) domain. ZO-1 is an integral member of the tight junction complex which forms a barrier to paracellular movement of substances, separating apical and basolateral fluids in relation to the epithelial cell layer. ZO-1 forms complexes with family members ZO-2, ZO-3, as well as occludin, cingulin, claudin-1-8, actin, alpha-catenin, the Ras-effector molecule AF-6, ZONAB, Apg-2, and the junctional adhesion molecules (JAM)-A-C. ZO-1 is thought to anchor the actin cytoskeleton to the tight junction. ZO-1 and ZO-2 have been shown to regulate cell cycle and proliferation with recent evidence highlighting the down-regulation of ZO-1 and ZO-2 with cancer progression.