ZK 756326, Tocris Bioscience™

Selective, non-peptide CCR8 agonist

Brand:  Tocris (Bio-Techne) 256550

Product Code. 13461484

Description

Selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.

Chemical Identifiers

• CAS: 874911-96-3
• Molecular Weight (g/mol): 429.382
• Synonym: zk756326 dihydrochloride, acmc-20p1e4, 2-2-4-3-phenoxyphenyl methyl piperazin-1-yl ethoxy ethanol dihydrochloride, 2-2-4-3-phenoxyphenyl methyl-1-piperazinyl ethoxy ethanol dihydrochloride
• IUPAC Name: 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride

• Molecular Formula: C21H30Cl2N2O3
• InChI Key: MPACCEKWFGWZHS-UHFFFAOYSA-N
• PubChem CID: 56972201
• SMILES: C1CN(CCN1CCOCCO)CC2=CC(=CC=C2)OC3=CC=CC=C3.Cl.Cl

Specifications

• Chemical Name or Material: ZK 756326
• CAS: 874911-96-3
• Synonym: zk756326 dihydrochloride, acmc-20p1e4, 2-2-4-3-phenoxyphenyl methyl piperazin-1-yl ethoxy ethanol dihydrochloride, 2-2-4-3-phenoxyphenyl methyl-1-piperazinyl ethoxy ethanol dihydrochloride
• SMILES: C1CN(CCN1CCOCCO)CC2=CC(=CC=C2)OC3=CC=CC=C3.Cl.Cl
• Molecular Weight (g/mol): 429.382
• Formula Weight: 429.38

• Quantity: 50mg
• Molecular Formula: C21H30Cl2N2O3
• InChI Key: MPACCEKWFGWZHS-UHFFFAOYSA-N
• IUPAC Name: 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride
• PubChem CID: 56972201
• Percent Purity: >99%