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YC 1, Tocris Bioscience™

Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Brand:  RD Systems (Bio-Techne) 4307/50

Code : Z1

Additional Details : Weight : 0.00050kg

Quantity 50mg

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Product Code. 13444534

  • £665.57 / 50mg

Estimated Shipment
09-07-2019

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Description

Description

Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.
Specifications

Chemical Identifiers

170632-47-0
304.349
yc-1, lificiguat, yc 1, 3-5'-hydroxymethyl-2'-furyl-1-benzylindazole, unii-515cc1wpte, 515cc1wpte, 3-5'-hydroxymethyl-2'-furyl-1-benzyl indazole, 5-1-benzyl-1h-indazol-3-yl furan-2-yl methanol, 5-1-phenylmethyl-1h-indazol-3-yl-2-furanmethanol, 2-furanmethanol,5-1-phenylmethyl-1h-indazol-3-yl
[5-(1-benzylindazol-3-yl)furan-2-yl]methanol
C19H16N2O2
OQQVFCKUDYMWGV-UHFFFAOYSA-N
5712
C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO

Specifications

YC 1
170632-47-0
yc-1, lificiguat, yc 1, 3-5'-hydroxymethyl-2'-furyl-1-benzylindazole, unii-515cc1wpte, 515cc1wpte, 3-5'-hydroxymethyl-2'-furyl-1-benzyl indazole, 5-1-benzyl-1h-indazol-3-yl furan-2-yl methanol, 5-1-phenylmethyl-1h-indazol-3-yl-2-furanmethanol, 2-furanmethanol,5-1-phenylmethyl-1h-indazol-3-yl
C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
304.349
304.34
50mg
C19H16N2O2
OQQVFCKUDYMWGV-UHFFFAOYSA-N
[5-(1-benzylindazol-3-yl)furan-2-yl]methanol
5712
>99%
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