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XRP44X, Tocris Bioscience™

Ras-Net pathway inhibitor

POA


Description

Description

Ras-Net (Elk-3) pathway inhibitor (IC50 = 10 - 20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2-M cell cycle arrest, suppresses growth of multiple cell types (IC50 ∽ 2 nM), inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro.