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XCT 790, Tocris Bioscience™

Selective ERRα inverse agonist

POA


Description

Description

Selective ERRα inverse agonist (IC50 = ∽400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.