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XAV 939, Tocris Bioscience™

Potent tankyrase inhibitor

Brand:  Tocris (Bio-Techne) 374810

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13433544

  • £173.46 / 10mg

Estimated Shipment date
from Supplier 20-11-2019

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Description

Description

Potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.
Specifications

Chemical Identifiers

284028-89-3
312.31
3,5,7,8-tetrahydro-2-4-trifluoromethyl phenyl-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiino 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydrothiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydro-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-3h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one
CHEBI:62878
C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
C14H11F3N2OS
KLGQSVMIPOVQAX-UHFFFAOYSA-N
2726824
2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one

Specifications

10mg
284028-89-3
3,5,7,8-tetrahydro-2-4-trifluoromethyl phenyl-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiino 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydrothiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydro-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-3h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one
C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
312.31
CHEBI:62878
>98%
XAV 939
C14H11F3N2OS
KLGQSVMIPOVQAX-UHFFFAOYSA-N
2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
2726824
312.31
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