VPS51 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA558869

Product Code. 15746741

Description

Immunogen sequence: FDPEVYLDKL RRECPLAQLM DSETDMVRQI RALDSDMQTL VYENYNKFIS ATDTIRKMKN DFRKMEDEMD RLATNMAVIT DFS Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.

Specifications

• Antigen: VPS51
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VPS51
• Gene Alias: 1110014N23Rik; 3110057M17Rik; AI837850; ANG2; ANG3; Another new gene 2 protein; C11orf2; C11orf3; Ffr; PP5382; Protein fat-free homolog; vacuolar protein sorting 51 homolog; vacuolar protein sorting 51 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 51 homolog; VPS51; VPS51 GARP complex subunit; VPS51, GARP complex subunit
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 738
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UID3
• Gene Symbols: VPS51
• Immunogen: Recombinant protein corresponding to Human VPS51
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only