Vinculin Mouse anti-Human, Mouse, Rat, Clone: 7F9, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-9777-82
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionAggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
|PBS with 0.09% sodium azide; pH 7.2|
|P85972, Q64727, P18206|
|RP11-178G16.3, CMD1W, MVCL|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot|
|22330, 305679, 7414|
For Research Use Only.