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TCR V beta 5.1/5.2 Mouse anti-Mouse, APC, Clone: MR9-4, eBioscience™
Mouse Monoclonal Antibody
£94.00 - £236.00
Specifications
Antigen | TCR V beta 5.1/5.2 |
---|---|
Clone | MR9-4 |
Target Species | Mouse |
Conjugate | APC |
Isotype | IgG1, kappa |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15598126
|
Affymetrix eBioscience
17-5796-80 |
25 μg |
£94.00
25µg |
Estimated Shipment 26-02-2021 |
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15508136
|
Affymetrix eBioscience
17-5796-82 |
100 μg |
£236.00
100µg |
Estimated Shipment 01-02-2021 |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.Specifications
TCR V beta 5.1/5.2 | |
Mouse | |
IgG1, kappa | |
Monoclonal | |
Liquid | |
Antibody | |
4° C, store in dark, DO NOT FREEZE! |
MR9-4 | |
APC | |
Flow Cytometry | |
Primary | |
Monoclonal | |
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2 | |
RUO |
For Research Use Only.