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TCR V alpha 24 J alpha 18 Monoclonal Antibody (6B11), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-5806-42

200.01 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.



Code : NEW

Additional Details : Weight : 0.23750kg

Product Code. 15579276

  • £300.00 / 100 tests
Estimated Shipment: 08-05-2024
to see stock.

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Description

Description

Description: The 6B11 monoclonal antibody reacts with an epitope of the CDR3 formed by the germ-line configuration of the V alpha 24 and J alpha 18 of the TCR alpha locus, which results in the expression of an invariant T-cell receptor (TCR) expressed by invariant NK T cells (iNKT). This TCR is homologous to the murine V alpha 14 J alpha 18. This TCR alpha chain pairs with a restricted set of rearranged TCR beta chains, with V beta 11 being the most prominent in humans. NK T cells are restricted by the CD1d molecule and are activated by a CD1d-presented glycolipid ligand, which results in the rapid production of IL-4, IL-13 and IFN gamma. Although iNKT cells have NK-like cytolytic activity, they are considered regulators of immune responses because they rapidly produce large amounts of both Th1 and Th2 cytokines in autoimmune disease, infectious disease, and cancer. The number of iNKT cells present in peripheral blood of normal humans shows considerable variability ranging from 0.01-1% of total peripheral T cells. Applications Reported: This 6B11 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 6B11 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

TCR V alpha 24 J alpha 18 Monoclonal antibody specifically detects TCR V alpha 24 J alpha 18 in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

TCR V alpha 24 J alpha 18
Monoclonal
5 μL/Test
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Mouse
100 Tests
Primary
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
6B11
PerCP-eFluor 710
Va24; Valpha24
Affinity chromatography
RUO
Human
Antibody
IgG1 κ
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