V alpha 24 J alpha 18 TCR Mouse anti-Human, PE, Clone: 6B11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5806-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15567026

Quantity Price
1 £ 170.59 / 100 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Quantity 100 tests
Antigen V alpha 24 J alpha 18 TCR
Primary or Secondary Primary
Conjugate PE
Host Species Mouse
Isotype IgG1
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone 6B11
Concentration 5μL (0.5μg)/test
Applications Flow Cytometry
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The 6B11 monoclonal antibody reacts with an epitope of the CDR3 formed by the germ-line configuration of the V alpha24 and J alpha18 of the TCR alpha locus, which results in the expression of an invariant T-cell receptor (TCR) expressed by invariant NK T cells (iNKT). This TCR is homologous to the murine V alpha 14 J alpha 18. This TCR alpha chain pairs with a restricted set of rearranged TCR beta chains, with V beta 11 being the most prominent in humans. NK T cells are restricted by the CD1d molecule and are activated by a CD1d-presented glycolipid ligand, which results in the rapid production of IL-4, IL-13 and IFN gamma. Although iNKT cells have NK-like cytolytic activity, they are considered regulators of immune responses because they rapidly produce large amounts of both Th1 and Th2 cytokines in autoimmune disease, infectious disease, and cancer. The number of iNKT cells present in peripheral blood of normal humans shows considerable variability ranging from 0.01-1% of total peripheral T cells.