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TCR V alpha 24 J alpha 18 Mouse anti-Human, PE, Clone: 6B11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-5806-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15567026

  • £183.00 / 100 tests

In stock, ready to ship: 1

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Description

Description

Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications

Specifications

TCR V alpha 24 J alpha 18
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
TCRV alpha 24 J alpha 18; TCRV alpha24 J alpha18; TCR V alpha24 J alpha18; Valpha24; Va24
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
Human
Flow Cytometry
6B11
PE
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
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