V alpha 24 J alpha 18 TCR Mouse anti-Human, FITC, Clone: 6B11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-5806-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586566

Quantity Price
1 £ 149.04 / 100 tests
EU Stock 2
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Description and Specification

Specification

Conjugate FITC
Quantity 100 tests
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen V alpha 24 J alpha 18 TCR
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Regulatory Status RUO
Primary or Secondary Primary
Concentration 5μL (0.25μg)/test
Format Conjugated
Isotype IgG1
Species Reactivity Human
Clone 6B11
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The 6B11 monoclonal antibody reacts with an epitope of the CDR3 formed by the germ-line configuration of the V alpha 24 and J alpha 18 of the TCR alpha locus, which results in the expression of an invariant T-cell receptor (TCR) expressed by invariant NK T cells (iNKT). This TCR is homologous to the murine V alpha 14J alpha 18. This TCR alpha chain pairs with a restricted set of rearranged TCR beta chains, with V beta 11 being the most prominent in humans. NK T cells are restricted by the CD1d molecule and are activated by a CD1d-presented glycolipid ligand, which results in the rapid production of IL-4, IL-13 and IFN gamma. Although iNKT cells have NK-like cytolytic activity, they are considered regulators of immune responses because they rapidly produce large amounts of both Th1 and Th2 cytokines in autoimmune disease, infectious disease, and cancer. The number of iNKT cells present in peripheral blood of normal humans shows considerable variability ranging from 0.01-1% of total peripheral T cells.