V alpha 11 TCR Rat anti-Mouse, PerCP-eFluor 710, Clone: RR8-1, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-5800-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15549276

Quantity Price
1 £ 75.3 / 25µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Host Species Rat
Isotype IgG2b
Concentration 0.2mg/mL
Quantity 25μg
Primary or Secondary Primary
Antigen V alpha 11 TCR
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Applications Flow Cytometry
Clone RR8-1
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Valpha11, Va11
Regulatory Status RUO
Conjugate PerCP-eFluor 710

This RR8-1 monoclonal antibody reacts with the mouse T cell receptor (TCR) V alpha 11 chain. Composed of an alpha and beta chain, TCR specificity is typically determined by Va, Ja, Vb, Db, and Jb gene rearrangement. The RR8-1 antibody recognizes the V beta 11 chain on T cells from mouse strains with the b (e.g., C57BL/6, B10) and d (e.g., DBA/1, DBA/2) haplotypes. V alpha 11+ T cells are absent in strains with the a (e.g., BALB/c, C3H) or c (e.g., SJL) haplotypes of the Tcra gene complex. Finally, V alpha 11 is expressed predominantly on CD4+ T cells.

The RR8-1 antibody recognizes the V alpha 11.1 and 11.2 alleles, but not 11.3. This antibody has been reported to stimulate V alpha 11+ T cells.