UBP 302, Tocris Bioscience™

Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)

Brand:  Tocris (Bio-Techne) 2079/10

Product Code. 13460434

Description

Potent and selective GLUK5 (GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ∽ 260-fold selectivity over AMPA receptors, ∽ 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.

Chemical Identifiers

• CAS: 745055-91-8
• Molecular Weight (g/mol): 333.3
• Synonym: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2, 4-dione

• Molecular Formula: C15H15N3O6
• InChI Key: UUIYULWYHDSXHL-NSHDSACASA-N
• PubChem CID: 6420161

Specifications

• Chemical Name or Material: UBP 302
• Quantity: 10mg
• Molecular Formula: C15H15N3O6
• InChI Key: UUIYULWYHDSXHL-NSHDSACASA-N
• IUPAC Name: 2-[[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid
• PubChem CID: 6420161

• CAS: 745055-91-8
• Purity Grade: >98%
• Synonym: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2, 4-dione
• SMILES: C1=CC=C(C(=C1)CN2C(=O)C=CN(C2=O)CC(C(=O)O)N)C(=O)O
• Molecular Weight (g/mol): 333.3
• Formula Weight: 333.3