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UBP 302, Tocris Bioscience™
Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)
Brand: Tocris (Bio-Techne) 2079/10
Code : Z1
Additional Details : Weight : 0.01000kg
Quantity | 10mg |
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Description
Potent and selective GLUK5 (GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ∽ 260-fold selectivity over AMPA receptors, ∽ 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.Chemical Identifiers
745055-91-8 | |
333.3 | |
s-1-2-amino-2-carboxyethyl-3-2-carboxybenzyl pyrimidine-2,4-dione, s-2-3-2-amino-2-carboxyethyl-2,6-dioxo-2,3-dihydropyrimidin-1 6h-yl methyl benzoic acid, ubc, tocris-2079, d09vyb, ubp hplc, s-1-2-amino-2-carboxyethyl-3-2-carboxybenzyl-pyrimidine-2,4-dione, 2-3-2s-2-amino-2-carboxyethyl-2,6-dioxopyrimidin-1-yl methyl benzoic acid, 2-3-2s-2-amino-3-hydroxy-3-oxopropyl-2,6-dioxopyrimidin-1-yl methyl benzoic acid, as-, a-amino-3-2-carboxyphenyl methyl-3,4-dihydro-2,4-dioxo-1 2h-pyrimidinepropanoic acid | |
2-[[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid |
C15H15N3O6 | |
UUIYULWYHDSXHL-NSHDSACASA-N | |
6420161 | |
C1=CC=C(C(=C1)CN2C(=O)C=CN(C2=O)CC(C(=O)O)N)C(=O)O |
Specifications
UBP 302 | |
745055-91-8 | |
s-1-2-amino-2-carboxyethyl-3-2-carboxybenzyl pyrimidine-2,4-dione, s-2-3-2-amino-2-carboxyethyl-2,6-dioxo-2,3-dihydropyrimidin-1 6h-yl methyl benzoic acid, ubc, tocris-2079, d09vyb, ubp hplc, s-1-2-amino-2-carboxyethyl-3-2-carboxybenzyl-pyrimidine-2,4-dione, 2-3-2s-2-amino-2-carboxyethyl-2,6-dioxopyrimidin-1-yl methyl benzoic acid, 2-3-2s-2-amino-3-hydroxy-3-oxopropyl-2,6-dioxopyrimidin-1-yl methyl benzoic acid, as-, a-amino-3-2-carboxyphenyl methyl-3,4-dihydro-2,4-dioxo-1 2h-pyrimidinepropanoic acid | |
C1=CC=C(C(=C1)CN2C(=O)C=CN(C2=O)CC(C(=O)O)N)C(=O)O | |
333.3 | |
333.3 |
10mg | |
C15H15N3O6 | |
UUIYULWYHDSXHL-NSHDSACASA-N | |
2-[[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid | |
6420161 | |
>98% |