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U0126, Tocris Bioscience™

Potent, selective inhibitor of MEK1 and 2

Brand:  Tocris (Bio-Techne) 1144/5

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 5mg

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Product Code. 13438733

  • £188.76 / 5mg

Estimated Shipment
08-07-2019

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Description

Description

Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Brain penetrant. Helps maintain human pluripotent stem cells in undifferentiated state.

Available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ . Negative Control also available.

Specifications

Chemical Identifiers

109511-58-2
380.488
1,4-diamino-2,3-dicyano-1,4-bis o-aminophenylmercapto butadiene, unii-8027p94hll, 2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile, 2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile, succinonitrile, bis amino o-aminophenylthio methylene, butanedinitrile, bis amino 2-aminophenyl thio methylene, 2z,3z-bis amino 2-aminophenyl sulfanyl methylene succinonitrile, 2z,3z-2,3-bis amino-2-aminophenyl sulfanyl-methylene butanedinitrile, biomolki_000002, biomolki2_000012
CHEBI:64208
C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
C18H16N6S2
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
3006531
(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile

Specifications

U0126
109511-58-2
1,4-diamino-2,3-dicyano-1,4-bis o-aminophenylmercapto butadiene, unii-8027p94hll, 2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile, 2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile, succinonitrile, bis amino o-aminophenylthio methylene, butanedinitrile, bis amino 2-aminophenyl thio methylene, 2z,3z-bis amino 2-aminophenyl sulfanyl methylene succinonitrile, 2z,3z-2,3-bis amino-2-aminophenyl sulfanyl-methylene butanedinitrile, biomolki_000002, biomolki2_000012
C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
380.488
CHEBI:64208
>98%
5mg
C18H16N6S2
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
3006531
380.48
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