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TSLP Receptor Mouse anti-Human, APC, Clone: 1A6, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5499-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15518126

  • £72.77 / 25 tests


Estimated Shipment date
from Supplier 02-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The eBio1A6 monoclonal antibody reacts with human thymic stromal-derived lymphopoietin receptor (TSLPR). TSLPR is an approximately 50kDa protein with significant similarity to the common gamma-chain. TSLPR complexes with IL-7R alpha (CD127) to form the high affinity receptor that binds thymic stromal-derived lymphopoietin (TSLP). Human TSLPR is expressed by monocytes and CD11c+ dendritic cells, and TSLP binding induces the expression of the Th2 cell-attracting chemokines CCL17 and CCL22. Furthermore, the TSLPR-induced activation of dendritic cells indirectly results in the increased secretion of Th cytokines IL-4, -5 and -13, which may be necessary for the regulation of CD4+ T cell homeostasis. In mice, deficiency of TSLPR has no effect on lymphocyte numbers, whereas double deficiency of TSLPR and common gamma-chain results in fewer lymphocytes than seen in mice deficient in the common gamma-chain alone. The eBio1A6 monoclonal antibody is able to cross-block binding of another anti-human TSLPR monoclonal antibody, 1D8.
Description & Specifications

Specifications

TSLP Receptor
eBio1A6 (1A6)
Allophycocyanin
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.06μg)/test
Conjugated
thymic stromal derived lymphopoietin receptor, CRLF-2
IgG2a
RUO
Primary
Human