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TSLP Rat anti-Mouse, Clone: eBio28F12 (28F12), Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-5491-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258647

  • £72.77 / 100µg


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For Research Use Only.


Description

Description

The monoclonal antibody eBio28F12 reacts with and inhibits the bioactivity of mouse TSLP. Thymic Stromal-Derived Lymphopoetin (TSLP) was first identified in the tissue culture supernatant of a thymic stromal cell line as a growth factor capable of inducing proliferation and differentiation of pre-B cells. It was later found to be closely related to another stromal cytokine, IL-7, with which it shares overlapping functions. Along with its proliferative effects on B cells, TSLP induces dendritic cells to support the differentiation of naïve T cells towards the Th2 lineage and may also be involved in the development of CD4+CD25+ regulatory T cells. The receptor for TSLP is heterodimeric and shares one subunit, IL-7Rα, with IL-7 and other members of the family, while the TSLPR subunit is unique to TSLP.

TSLP expression can be induced by a variety of inflammatory cytokines and TLR ligands. Expression is regulated by NF-κB and has been detected in epithelial cells, stromal cells, and basophils. Elevated levels of TSLP are associated with asthma and atopic dermatitis, which are both Th2-mediated inflammatory conditions. It is believed that chronic overexpression of TSLP may result in increased sensitivity to allergens, resulting in susceptibility to these conditions.

Specifications

Specifications

TSLP
eBio28F12 (28F12)
Unconjugated
Purified
Rat
100μg
Store at 2-8°C.
Monoclonal
Cytokine Neutralization
1mg/mL
aqueous buffer, no sodium azide
thymic stromal derived lymphopoietin
IgG2a
RUO
Primary
Murine
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