TRA-1-81 (podocalyxin) Mouse anti-Human, Clone: TRA-1-81, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8883-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288107

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunoprecipitation
Applications Western Blotting
Quantity 25μg
Species Reactivity Human
Isotype IgM
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Format Purified
Host Species Mouse
Concentration 0.5mg/mL
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, contains carrier protein/stabilizer if necessary
Clone TRA-1-81
Antigen TRA-1-81 (podocalyxin)
Regulatory Status RUO

The TRA-1-81 antibody recognizes a protein expressed on undifferentiated human embryonic stem cells (ES), embryonic carcinoma cells (EC), and embryonic germ cells (EG). Like other stem cell specific markers, the epitope recognized by the TRA-1-81 antibody is lost upon cell differentiation. The TRA-1-81 epitope is resistant to neuraminidase digestion, unlike the epitope recognized by the related TRA-1-60 antibody. The TRA-1-81 antibody is known to specifically recognize a carbohydrate epitope on a keratan sulfated glycoprotein recently identified as podocalyxin, a member of the CD34-related family of sialomucins. Podocalyxin is a transmembrane glycoprotein originally identified on epithelial glomerular cells known as podocytes, and the protein has also been implicated in the development of aggressiveness in a variety of cancers, including breast and prostate cancer.