TRA-1-60 (podocalyxin) Mouse anti-Human, Clone: TRA-1-60, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-8863-82
Code : Z2
Additional Details : Weight : 0.01000kg
DescriptionThe TRA-1-60 antibody recognizes a protein expressed on undifferentiated human embryonic stem cells (ES), embyronal carcinoma cells (EC), and embryonic germ cells (EG). Like other stem cell specific markers, the epitope recognized by the TRA-1-60 antibody is lost upon cell differentiation. Contrary to early reports that the TRA-1-60 epitope can be destroyed by neuraminidase digestion, new strudies have shown that TRA-1-60 recognizes a neurominidase resistent antigen. The TRA-1-60 antibody is known to specifically recognize a carbohydrate epitope on a keratan sulfated glycoprotein recently identified as podocalyxin, a member of the CD34-related family of sialomucins. Podocalyxin is a transmembrane glycoprotein originally identified on epithelial glomerular cells known as podocytes, and the protein has also been implicated in the development of aggressiveness in a variety of cancers, including breast and prostate cancer.
|aqueous buffer, 0.09% sodium azide, contains carrier protein/stabilizer if necessary|
|Store at 2-8°C.|