TRA-1-60 (podocalyxin) Mouse anti-Human, Clone: TRA-1-60, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8863-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258107

Quantity Price
1 £ 146.13 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Quantity 100μg
Clone TRA-1-60
Applications Flow Cytometry
Applications Immunohistochemistry
Applications Immunoprecipitation
Applications Western Blotting
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Conjugate Unlabeled
Host Species Mouse
Isotype IgM
Storage Requirements Store at 2-8°C.
Concentration 0.5mg/mL
Format Purified
Antigen TRA-1-60 (podocalyxin)
Formulation aqueous buffer, 0.09% sodium azide, contains carrier protein/stabilizer if necessary
Regulatory Status RUO

The TRA-1-60 antibody recognizes a protein expressed on undifferentiated human embryonic stem cells (ES), embyronal carcinoma cells (EC), and embryonic germ cells (EG). Like other stem cell specific markers, the epitope recognized by the TRA-1-60 antibody is lost upon cell differentiation. Contrary to early reports that the TRA-1-60 epitope can be destroyed by neuraminidase digestion, new strudies have shown that TRA-1-60 recognizes a neurominidase resistent antigen. The TRA-1-60 antibody is known to specifically recognize a carbohydrate epitope on a keratan sulfated glycoprotein recently identified as podocalyxin, a member of the CD34-related family of sialomucins. Podocalyxin is a transmembrane glycoprotein originally identified on epithelial glomerular cells known as podocytes, and the protein has also been implicated in the development of aggressiveness in a variety of cancers, including breast and prostate cancer.